Hydrazide-Bearing Folda-Bonder for Modular Synthesis of π-Stacked Ring-in-Rings Complexes

Abstract

Pseudostatic supramolecular preorganization coupled with dynamic covalent chemistry enables the selective construction of structurally defined ring-in-rings complexes. Cucurbit[8]uril folds a bis(acylhydrazide) into a reactive 1:1 complex that captures various aromatic dialdehydes in water, reaching a near-quantitative NMR yield (up to 97%). Single crystals can be obtained directly from post-reaction solutions without product isolation. Four related structures reveal robust cofacial π-stacking together with core-dependent dynamics and higher order packing.

Xiujie Han

PhD Candidate (2024)

Han Xiujie is earnest and hardworking. She is interested in the field of molecular assembly.

Jia Liu

PhD graduate (2021)

Enthusiastic, creative, optimistic, and easygoing.

Yibin Sun

Assistant Professor

Research interests: catassembly, assembly kinetics, protein-protein assembly, and protein engineering

Guanglu Wu

Professor

Research interests: multi-component functional assemblies, noncovalent dimerization, supramolecular catalysis, and smart soft matter