A Minimalist Binary Vaccine Carrier for Personalized Postoperative Cancer Vaccine Therapy

Image credit: Wiley

摘要

In recent years, significant evolutions have been made in applying nanotech-nologies for prophylactic and therapeutic cancer vaccine design. However, the clinical translation of nanovaccines is still limited owing to their com-plicated compositions and difficulties in the spatiotemporal coordination of antigen-presenting cell activation and antigen cross-presentation. Herein, a minimalist binary nanovaccine (BiVax) is designed that integrates innate stimulating activity into the carrier to elicit robust antitumor immunity. The authors started by making a series of azole molecules end-capped polyeth-ylenimine (PEI-M), and were surprised to find that over 60% of the PEI-M polymers have innate stimulating activity via activation of the stimulator of interferon genes pathway. PEI-4BImi, a PEI-M obtained from a series of polymers, elicits robust antitumor immune responses when used as a subcutaneously injected nanovaccine by simply mixing with ovalbumin anti-gens, and this BiVax system performs much better than the traditional ternary vaccine system, as well as, commercialized aluminum-containing adjuvants. This system also enables the fast preparation of personalized BiVax by com-positing PEI-4BImi with autologous tumor cell membrane protein antigens, and a 60% postoperative cure rate is observed when combined with immune checkpoint inhibitors.

曲浩沅
曲浩沅
博士研究生(2022级)

这位同学是道地的长春人,为人友善,平易近人,有任何困难都可以找他讨论。

吴光鹭
吴光鹭
课题组负责人

研究方向:多组分功能组装体;非共价二聚体;超分子催化;智能软物质