From May 24 to 31, 2025, the 19th International Symposium on Macrocyclic and Supramolecular Chemistry 2025 (ISMSC2025) was successfully held in Kyoto, Japan. As a premier global event in the field, the conference brought together over 1,000 leading experts and emerging scholars from around the world to discuss the latest advances in macrocyclic and supramolecular chemistry.